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Chronic kidney disease can be an independent disease or a secondary disease- associated with some other disease. One among these is Rheumatoid Arthritis (RA). Today, in order to diagnose certain kidneys diseases successfully used methods of determine в₂-microglobulin and the rate of progression of renal disease. For determination of depth of renal lesion dynamics of transforming growth factor в₁ (TGF-в₁) in blood plasma of patients has been successfully used.