Aim was to estimate the efficacy of combined cryochemical ablation in patients with metachronous colorectal liver metastases (CRLM). 205 case histories of patients with metachronous unresectable CRLM's was analysed in period 2006-2016. The I group of patients (n=139) was treated with cryoablation only. The II group (n=66) underwent 10% calcium chloride intratumoral injection with consequent cryoablation (cryochemoablation). Specific complications in both groups was 4,3% and 4,5% correspondingly (p=0,31). Mortality, associated with procedures, wasn't detected. Сomplete response was obtained in 13,4% and 21,6%, partial response was 35,1% and 47,9%, stable disease was 19,1% and 25,1%, progressive disease was 10,6% and 5,4% (p<0,05). Conversion to resectability has been achieved in 24,6% and 36,4% correspondingly (p=0,043). Combined cryochemical ablation is safe method with clear trend to better response of local control and may be used for treatment of patients with unresectable metachronous CRLM.