205 case histories of patients with metachronous unresectable CRLM's was analysed in period 2006-2016. The I group of patients (n=139) was treated with cryoablation only. The II group (n=66) underwent 10% calcium chloride intratumoral injection with consequent cryoablation (cryochemoablation). Specific complications in both groups was 4,3% and 4,5% correspondingly (p=0,31). Mortality, associated with procedures, wasn't detected. Complete response was obtained in 13,4% and 21,6%, partial response was 35,1% and 47,9%, stable disease was 19,1% and 25,1%, progressive disease was 10,6% and 5,4% (p<0,05). Conversion to resectability has been achieved in 24,6% and 36,4% correspondingly (p=0,043). Combined cryochemical ablation is safe method with clear trend to better response of local control and may be used for treatment of patients with unresectable metachronous CRLM.