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The article focuses on application of simulation technologies in process of teaching of theoretical disciplines on the example of discipline “Physiology”. Creation of models of clinical situations and physiological systems that can be applied for studying of discipline “Physiology”, realization of practical classes using those models, assessment of level of student knowledge after application of mentioned method of training were done. Flaws and advantages of that training method were determined. Simulation training was proved to be effective for improvement of student theoretical knowledge, stimulation of their self-development and formation of basis of clinical thinking in study of theoretical disciplines in medical university.