Purpose: to investigate the effect of apple pectin on individual metabolic parameters in animals with acute alcohol intoxication

Materials and methods: Acute alcohol intoxication was modeled on 30 white rats weighing 180-200 g of both sexes by infusions 40% of ethanol into the stomach. The rate was 2 ml / 100 g body weight. Pectin was injected e into the stomach at a rate of 0.2 g / 100 g of body weight; comparative preparations were coal powder activated in the amount of 0.25 g / d of silicon dioxide of 0.025 g per 100 g of body weight. Pectin and comparison drugs were injected for 1 hour before and after the infusions of ethanol. Animals were extracted from the experiment under thiopental anesthesia on the 3rd day and studied cholesterol and glucose levels in serum.

Research results. Blood glucose levels significantly differed from the norm (5.0 ± 0.15 mmol / l) in animals fed ethanol without further treatment (4.23 ± 0.12 mmol / L) and treated with silicon dioxide (4, 22 ± 0.21 mmol / L). Indicators in groups treated with apple pectin (4.67 ± 0.13 mmol / l) and activated charcoal (4.67 ± 0.21 mmol / l) were slightly lower than normal (p <0.05). In order to determine the functional state of the liver, the level of cholesterol was checked. Was found out that the amount of cholesterol significantly increased only in the group of alcoholic untreated animals (3.42 ± 0.15 versus 3,04 ± 0.11 mmol / l in intact, p005).

Conclusions On the model of acute alcohol intoxication, we determined the significant effect of ethanol on the level of glucose in blood serum of rats, which is due to inhibition of enzymes involved in glycogenolysis and gluconeogenesis. The use of apple pectin, activated charcoal and silicon dioxide significantly reduces the level of hypoglycemia in experimental animals. In the acute experiment, we also noted the effect of the substances studied from the lipid metabolism of enterosorbents: cholesterol levels were statistically significant only in the untreated animal group compared to normal. Consequently, apple pectin has an effect on metabolic processes under acute alcohol intoxication, which equates to the influence of reference adsorbents.