INTRODUCTION: Systemic Scleroderma (SS) known as diffuse scleroderma or systemic sclerosis is an autoimmune disease of the connective tissue characterized by changes in the texture and appearance of the skin due to increased collagen production.
SS affects more blacks than whites, Japanese have a lower prevalence than whites but the effects on the whites are greater than in blacks. The highest rates have been discovered in Choctaw Native Americans. In Ternopil there are about 50cases within a year and affects young adults and middle aged people. 
AIM: This study presents a case of a 49 year old woman with SYSTEMIC SCLERODERMA WITH SJOGREN SYNDROME, WITH INVOLVEMENT OF THE JOINTS,SKIN,LUNGS,DIGESTIVE TRACT.
MATERIALS AND METHODS: Case history. 
RESULTS: A 49 years old woman with complains of dry eyes came to the ophthalmologist in 2014; she has had such symptoms for 10 years. Serological test revealed positive centromere B. VS was normal and all other organs normal except the lungs that had fibrotic rales symmetrically. In CBC her ESR was high. All other tests were normal. Diagnosis made that year was ESOPHAGITIS AND PNEUMOFIBROSIS WITH SWOLLEN SKIN ABOVE WRIST, she was treated with Alprostan IV 200 mg/day for 5-10 days, methylprednisolone 8mg/day, omeprazole 10mg once daily. She comes for check up once every year. 2015: severe case of arthritis and esophagitis, treatment Alprostan, methylprednisolone 16mg/day, d-penicillamine 250mg/day. 2016-2017,Treatment Alprostan IV, methylprednisolone 8mg, d-penicillamine. 2018,Alprostan. 2019: overall condition is satisfactory. Treatment Alprostan.
MAIN DIAGNOSIS: SYSTEMIC SCLERODERMA WITH SJOGREN SYNDROME (DRY EYES COMPLICATED BY KERACONJUCTIVITIS) WITH INVOLVEMENT OF SKIN, LUNGS, JOINTS AND DIGESTIVE TRACT.

SUMMARY: Successful treatment of SSc in patient with Raynaud Phenomenon