Endometriosis is one of the most mysterious and unresolved problem in modern gynecology, taking the third place in the structure of gynecological diseases. In the genesis of endometriosis important role belongs to the metabolism genes, which are characterized by a large variability of molecular structure of  DNA. It is proved that implantation of endometrial cells and their proliferation is provided, if a woman abuses humoral and cellular immunity.

The aim of  our study was to determine the  role of polymorphisms genes of detoxification system and immunedependent mechanisms in the development of  endometriosis.

Material and methods. Surveyed 102 patients with internal genital endometriosis. The polymerase chain reaction investigated the frequency of polymorphic variants of genes GSTT1 and GSTM1. DNA extraction from peripheral blood was perfomed using the test system «AmpliSens». Determination of interleukins levels in serum was perfomed by the method monoparentale analysis using the test-systems for IFA.

Results of the study and their discussion. The results of the conducted researches have allowed to establish that genital endometriosis is significantly associated with deleting polymorphisms genes of detoxication system. Also, it was found that patients with internal endometriosis there is a hyperproduction of proinflammatory cytokines  and tumor necrosis factor-α.

Conclusions. Research factors of immune regulation, and gene deletions of the glutation-S-transferase is a promising for future research in terms of studying them as a potential marker for noninvasive diagnosis of endometriosis.