Chukur Petro

Changes in the structural and functional state of bone tissue of the lumbar spine in patients with follicular non-Hodgkin's lymphoma

Department of Oncology, Radiation Diagnostics and Therapy and Radiation Medicine

Ternopil State Medical University

named after I. Ya. Gorbachevsky of the Ministry of Health of Ukraine »

Scientific supervisor - prof. Zhulkevych I.V.

Ternopil, Ukraine

Relevance Follicular lymphoma is one of most not investigated lymphomas among middle aged and elderly people.

The purpose of the study is to study the structural and functional state of bone tissue of the lumbar spine in men with follicular non-Hodgkin's lymphoma on diagnostic and chemotherapeutic stages of treatment.

Materials and methods. The work is based on archival evaluation of computer tomography data of 40 patients (mean age 61.41 ± 6.36 years) who were inpatient treatment at the Ternopil Regional Clinical Oncology Center for 2010-2018.

The method for evaluating the structure of the vertebrae was to use specialized software (the medical image analysis program - ImageJ with the application BoneJ, USA).

Results Evaluation of individual values of densitometric solidity of the vertebrae of the lumbar spine in the examined patients at the diagnostic stage allowed to reveal that the normal mineral density of the bone tissue was 7 examined, osteopenia 12, and osteoporotic changes 21.

Treatment with the protocol of CHOP led to a further significant decrease in the densitometric density of the trabecular component of the vertebrae.

At the end of the chemotherapeutic stage, no normal state of densitometric density of bone tissue was detected in any of the patients examined, 17 were osteopenic, and osteoporotic changes were 23.

According to the data, there was a significant decrease in the volume of bone mass of the trabecular matrix during the course of chemotherapeutic treatment, and the latter was due to a significant decrease in the index of the mineral component.

Conclusions The conduct of polychemotherapy treatment leads to a further decrease in the densitometric density of the vertebrae of the lumbar spine, which in digital terms reaches 11-26% of the baseline. The changes in the densitometric density of the vertebrae occur due to a significant decrease in the index of the mineral component of the trabecular tissue.